1. Jürgen Behrens is at the Nikolaus-Fiebiger Center for Molecular Medicine, University Erlangen, Glückstr. 6, 91341 Erlangen, Germany.
   e-mail: jbehrens@molmed.uni-erlangen.de

Abstract

The tumour suppressor VHL is known to suppress hypoxia-induced gene expression by degrading HIF family transcription factors. Evidence that VHL also targets the oncoprotein -catenin for degradation highlights a new road to transformation by loss of VHL.

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