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Letter

Nature Cell Biology 10, 61–69 (1 January 2008) | doi:10.1038/ncb1669

Epithelial coating controls mesenchymal shape change through tissue-positioning effects and reduction of surface-minimizing tension

Hiromasa Ninomiya & Rudolf Winklbauer

Signalling between mesenchymal and epithelial cells has a profound influence on organ morphogenesis. However, less is known about the mechanical function of epithelial–mesenchymal interactions.