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Letter

Nature Cell Biology 10, 102–109 (1 January 2008) | doi:10.1038/ncb1674

Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription

Ray Kit Ng & J. B. Gurdon

The remarkable stability of gene expression in somatic cells is exemplified by the way memory of an active gene state is retained when an endoderm cell nucleus is transplanted to an enucleated egg. Here we analyse the mechanism of a similar example of epigenetic memory.