1. Christoph J. Burckhardt & Urs F. Greber are at the Institute of Zoology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
   e-mail: ufgreber@zool.uzh.ch

Abstract

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

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