News and Views
Nature Cell Biology 10, 7 - 9 (2008)
doi:10.1038/ncb0108-7
Epigenetic memory: H3.3 steps in the groove
Nicolas Lacoste1 & Geneviève Almouzni1
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Nicolas Lacoste and Geneviève Almouzni are at the Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS/Institut Curie 26, Rue d'Ulm, 75248 Paris Cedex 5, France.
e-mail: genevieve.almouzni@curie.fr
Abstract
Successful animal cloning after nuclear transfer requires efficient reprogramming to achieve totipotency. Erasure of pre-existing marks is not always efficient and some genes can escape reprogramming and maintain their original active transcriptional state. Ng and Gurdon propose that the histone H3.3 variant is a key player in this process.
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