News and Views
Nature Cell Biology 10, 16 - 18 (2008)
doi:10.1038/ncb0108-16
Getting invasive with GEP100 and Arf6
Ferran Valderrama1 & Anne J. Ridley1
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Ferran Valderrama and Anne J. Ridley are at the Randall Division of Cell and Molecular Biophysics, New Hunts House, Guy's Campus, King's College London, SE1 1UL, UK.
e-mail: anne.ridley@kcl.ac.uk
Abstract
When cancers spread, they detach from their neighbouring cells and invade the surrounding tissues to reach blood or lymphatic vessels. EGF receptors induce cancer invasion by directly activating GEP100, one of several potential activators of the GTP-binding protein Arf6.
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