News and Views
Nature Cell Biology 10, 11 - 13 (2008)
doi:10.1038/ncb0108-11
Cilia put a brake on Wnt signalling
Xi He1
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Xi He is at the F. M. Kirby Neurobiology Center, Children's Hospital Boston, Harvard Medical School, Enders 461.2, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
e-mail: xi.he@childrens.harvard.edu
Abstract
Two studies suggest that the primary cilium, a microtubule-based structure protruding from the surface of most vertebrate cells, has a role in restraining Wnt/
-catenin signalling. These findings have implications for the pathogenesis of a plethora of diseases associated with abnormal cilia; however, the mechanism linking Wnt signalling and cilia remains a mystery.
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