Table of contents


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News and Views

From small flies come big discoveries about size control ppE191 - E193

Bruce A. Edgar

doi:10.1038/70217


Lipids: defining the shape of things to come pE192

Annette Thomas

doi:10.1038/70219


Nitric oxide pumps up calcium signalling ppE193 - E195

Andrew Charles

doi:10.1038/70221


SMAD destruction turns off signalling ppE195 - E197

Carl-Henrik Heldin & Peter ten Dijke

doi:10.1038/70223


Breaking through an actin cloud ppE197 - E198

Ken Jacobson

doi:10.1038/70225


Survivin' cell-separation anxiety ppE199 - E200

John C. Reed & Steven I. Reed

doi:10.1038/70227


A new piece in the telomere jigsaw pE200

Amanda Tromans

doi:10.1038/70228


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Historical Perspective

One hundred years of membrane permeability: does Overton still rule? ppE201 - E202

Qais Al-Awqati

doi:10.1038/70230


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Technology Review

'Shocking' developments in chick embryology: electroporation and in ovo gene expression ppE203 - E207

Nobue Itasaki, Sophie Bel-Vialar & Robb Krumlauf

doi:10.1038/70231


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Review

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? ppE209 - E216

Matthew G. Vander Heiden & Craig B. Thompson

doi:10.1038/70237


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Articles

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function pp461 - 466

Fengzhi Li, Elizabeth J. Ackermann, C. Frank Bennett, Annette L. Rothermel, Janet Plescia, Simona Tognin, Antonello Villa, Pier Carlo Marchisio & Dario C. Altieri

doi:10.1038/70242

See also: News and Views by Reed & Reed


Coordination of calcium signalling by endothelial-derived nitric oxide in the intact liver pp467 - 471

Sandip Patel, Lawrence D. Robb-Gaspers, Kerri Anne Stellato, Mimi Shon & Andrew P. Thomas

doi:10.1038/70249

See also: News and Views by Charles


Ubiquitin-dependent degradation of TGF-beta-activated Smad2 pp472 - 478

Roger S. Lo & Joan Massagué

doi:10.1038/70258

See also: News and Views by Heldin & ten Dijke


Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response pp479 - 485

Taiichi Katayama, Kazunori Imaizumi, Naoya Sato, Ko Miyoshi, Takashi Kudo, Junichi Hitomi, Takashi Morihara, Takunari Yoneda, Fumi Gomi, Yasutake Mori, Yuka Nakano, Junji Takeda, Takehide Tsuda, Yasuto Itoyama, Ohoshi Murayama, Akihiko Takashima, Peter St George-Hyslop, Masatoshi Takeda & Masaya Tohyama

doi:10.1038/70265


CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans pp486 - 492

Hui Feng, Weiwei Zhong, George Punkosdy, Subin Gu, Liang Zhou, Erin K. Seabolt & Edward T. Kipreos

doi:10.1038/70272


Cooperative symmetry-breaking by actin polymerization in a model for cell motility pp493 - 499

Alexander van Oudenaarden & Julie A. Theriot

doi:10.1038/70281

See also: News and Views by Jacobson


Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB pp500 - 506

Javier Verdu, Michael A. Buratovich, Elizabeth L. Wilder & Morris J. Birnbaum

doi:10.1038/70293

See also: News and Views by Edgar


Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas pp507 - 513

Kathryn M. Eisenmann, James B. McCarthy, Melanie A. Simpson, Patricia J. Keely, Jun-Lin Guan, Kouichi Tachibana, Louis Lim, Ed Manser, Leo T. Furcht & Joji Iida

doi:10.1038/70302


Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans pp514 - 521

Risa Kitagawa & Ann M. Rose

doi:10.1038/70309


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Brief Communication

The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi pp523 - 525

Christiane Walch-Solimena & Peter Novick

doi:10.1038/70319


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