News and Views abstract
Nature Cell Biology 1, E195 - E197 (1999)
doi:10.1038/70223
SMAD destruction turns off signalling
Carl-Henrik Heldin1,2 & Peter ten Dijke3
- Carl-Henrik Heldin is at the Ludwig Institute for Cancer Research, Box 595, S-751 24 Uppsala, Sweden.
- e-mail: C-H.Heldin@LICR.uu.se
- Peter ten Dijke is in the Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Correspondence to: Peter ten Dijke3 e-mail: ptdijke@nki.nl
Abstract
SMAD proteins are key signal-transduction molecules whose activity must be tightly regulated. SMADs can be activated by phosphorylation, and at least one, Smad2, can be deactivated by degradation by protein-crunching proteasomes in the nucleus.
