News and Views abstract
Nature Cell Biology 1, E177 - E179 (1999)
doi:10.1038/15614
Sensor-less checkpoint activation?
Rhett Michelson1 & Ted Weinert1
- Rhett Michelson and Ted Weinert are in the Department of Molecular and Cellular Biology, University of Arizona, Tucson , Arizona 85721-0106, USA.
Correspondence to: Ted Weinert1 e-mail: tweinert@u.arizona.edu
Abstract
DNA damage activates a set of proteins whose job is to delay the cell cycle until the damage is repaired. This process was thought to involve the detection of damage by sensor proteins, which transmit a signal to a key protein kinase and thence to downstream targets. Unexpectedly, damage can also activate the kinase directly.
