News and Views abstract
Nature Cell Biology 1, E175 - E177 (1999)
doi:10.1038/15611
Saying a firm 'no' to DNA re-replication
J. Julian Blow1 & Tatyana A. Prokhorova1
- J. Julian Blow and Tatyana A. Prokhorova are in the CRC Chromosome Replication Research Group, Department of Biochemistry, University of Dundee, MSI/WTB Complex, Dow Street, Dundee DD1 5EH, UK.
Correspondence to: J. Julian Blow1 e-mail: j.j.blow@dundee.ac.uk
Abstract
Yeast cells exclude the DNA-replication-initiation factor Mcm4 from the nucleus during the S and G2 phases of the cell cycle, when active replication 'origins' must not reassemble. This exclusion is dependent on cyclin-dependent kinases and provides a general mechanism for preventing re-replication of DNA in a single cell cycle.
