Nature Cell Biology
1, 409 - 414 (1999)
Published online: 19 January 1999; | doi:10.1038/15640
A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+
homeostasisOlugbenga A. Adebanjo1, 5, Hindupur K. Anandatheerthavarada2, Anatoliy P. Koval1, Baljit S. Moonga1, 5, Gopa Biswas2, Li Sun1, 5, Bali R. Sodam1, 5, Peter J. R. Bevis1, 5, Christopher L.-H. Huang3, Solomon Epstein1, F. Anthony Lai4, Narayan G. Avadhani2
& Mone Zaidi51
Department of Medicine, Medical College of Pennsylvania
School of Medicine and Veterans Affairs Medical Center,
Philadelphia
, Pennsylvania 19104, USA
2
Department of Animal Biology, School of Veterinary
Medicine, University of Pennsylvania, Philadelphia,
Pennsylavania 19104, USA
3
The Physiological Laboratory, University of Cambridge
, Cambridge CB2 3EG, UK
4
University of Wales College of Medicine,
Heath Park, Cardiff, CF14 4XN, UK
5
Division of Endocrinology, Mailbox 1055, Mount Sinai
School of Medicine, One Gustave Levy Place, New
York, New York 10029, USA
Correspondence should be addressed to Mone Zaidi e-mail: mone.zaidi@mssm.eduNucleoplasmic calcium ions (Ca2+) influence nuclear functions
as critical as gene transcription, apoptosis, DNA repair, topoisomerase activation
and polymerase unfolding. Although both inositol trisphosphate receptors and
ryanodine receptors, types of Ca2+ channel, are present in
the nuclear membrane, their role in the homeostasis of nuclear Ca2+
remains unclear. Here we report the existence in the inner nuclear
membrane of a functionally active CD38/ADP-ribosyl cyclase that has its catalytic
site within the nucleoplasm. We propose that the enzyme catalyses the intranuclear
cyclization of nicotinamide adenine dinucleotide to cyclic adenosine diphosphate
ribose. The latter activates ryanodine receptors of the inner nuclear membrane
to trigger nucleoplasmic Ca2+ release.
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