Focus on Membrane Traffic abstract
Nature Cell Biology 1, E147 - E148 (1999)
doi:10.1038/14099
The works of GLI and the power of Hedgehog
Ariel Ruiz i Altaba1
- Ariel Ruiz i Altaba is at the Skirball Institute, NYU School of Medicine, 540 First Avenue, New York , New York 10016, USA.
Correspondence to: Ariel Ruiz i Altaba1 e-mail: ria@saturn.med.nyu.edu
Abstract
GLI proteins control cell fate, growth and patterning. In unstimulated cells, several mechanisms ensure the active repression of GLI target genes. Hedgehog signalling switches on a sensitive activation programme through coordinate effects on GLI proteins, resulting in nuclear accumulation of transcriptionally active GLI forms.
