Focus on Membrane Traffic abstract
Nature Cell Biology 1, E145 - E147 (1999)
doi:10.1038/14097
Motivating endosome motility
Suzanne R. Pfeffer1
- Suzanne R. Pfeffer is in the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA.
Correspondence to: Suzanne R. Pfeffer1 e-mail: pfeffer@cmgm.stanford.edu
Abstract
The GTPase Rab5 regulates the fusion of early endosomes. Activated Rab5 interacts with phosphatidylinositol-3-OH kinase and with the endosome-tethering protein EEA1. These interactions lead to enhanced motility of endosomes along microtubules.
