Focus on Membrane Traffic abstract
Nature Cell Biology 1, E143 - E145 (1999)
doi:10.1038/14094
Biddable death
Shigekazu Nagata1
- Shigekazu Nagata is in the Department of Genetics, and CREST, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Correspondence to: Shigekazu Nagata1 e-mail: nagata@genetic.med.osaka-u.ac.jp
Abstract
Mice lacking the pro-apototic protein Bid are resistant to the lethal effects of 'death-factor' signals relayed through Fas. But whereas Bid-deficient hepatocytes are resistant to Fas-mediated apoptosis, thymocytes and embryonal fibroblasts are not. This confirms the cell-type specificity of the Bid-dependent mitochondrial apoptotic pathway.
