Nature Cell Biology
1, E141 - E143 (1999)
doi:10.1038/14090
NSF is up to new tricksThomas L. Schwarz
Thomas L. Schwarz is in the Department of Molecular
and Cellular Physiology, School of Medicine, Beckman Center, Stanford University
Medical Center, Stanford, California 94305-5345
, USA.
Correspondence should be addressed to Thomas L. Schwarz tschwarz@leland.stanford.eduMembrane trafficking depends on NSF, an ATPase that dissociates a complex
of membrane proteins called SNAREs. A particular NSF mutant apparently lacks
ATPase activity and cannot dissociate SNAREs, but can still promote membrane
fusion in an in vitro assay. Might NSF, in certain systems, have actions
we do not yet appreciate?
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