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Nature Cell Biology 1, E125–E127 (1 September 1999) | doi:10.1038/12956

Meiosis: Rec8 is the reason for cohesion

Chatanika Stoop-Myer & Angelika Amon

During meiosis, sister chromatids produced by chromosome duplication are held together by Rec8, a meiosis-specific cohesion protein. Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion.