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Nature Cell Biology 1, E119–E121 (1 September 1999) | doi:10.1038/12947
Kinesin: the tail unfolds
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Abstract
The cargo-binding tail of the motor protein kinesin acts as a regulator of kinesin-driven vesicle transport. In the absence of bound cargo, the kinesin tail interacts with the motor domains and inhibits their activity. Cargo binding blocks this interaction and relieves the inhibition.
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