News and Views abstract
Nature Cell Biology 1, E117 - E119 (1999)
doi:10.1038/12944
Wounding Smad
Joan Massagué1
-
Joan Massagué is at the Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
e-mail: j-massague@ski.mskcc.org
Abstract
TGF-
is a cytokine that enhances wound healing, a process involving diverse TGF--responsive cell types. Mice with a deletion of the Smad3 gene exhibit an increased rate of wound healing. The lack of Smad3 seems to modify the cellular response to TGF- and may suggest an intriguing molecular basis to this process.
