News and Views abstract
Nature Cell Biology 1, E113 - E115 (1999)
doi:10.1038/12939
The mesh hypothesis of Golgi dynamics
Christoph Lorra & Wieland B. Huttner
- Christoph Lorra and Wieland B. Huttner are in the Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany
- and Max-Planck-Institute of Molecular Cell Biology and Genetics, D-01307 Dresden, Germany.
Correspondence to: e-mail: christoph.lorra@urz.uni-heidelberg.de e-mail: whuttner@sun0.urz.uni-heidelberg.de
Abstract
The GTP-binding protein ARF induces the recruitment to the Golgi membrane of kinases that catalyse the synthesis of the lipid phosphatidylinositol-4,5-bisphosphate. This lipid acts as a binding site for certain actin-binding proteins, which may change the Golgi membrane skeleton to a form that allows membrane traffic.
