Table of contents


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Editorial

Investing in the future pE81

doi:10.1038/12130


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News and Views

Closing in on rhombomere boundaries ppE83 - E85

Andrew Lumsden

doi:10.1038/12078


Connections count in cell migration ppE85 - E87

Kristiina Vuori & Erkki Ruoslahti

doi:10.1038/12081


Coupling ATP hydrolysis to mechanical work ppE87 - E89

Alex E. Knight & Justin E. Molloy

doi:10.1038/12083


Knocking signalling out of the dystrophin complex ppE89 - E91

David S. Bredt

doi:10.1038/12085


Kip1 meets SKP2: new links in cell-cycle control ppE91 - E93

Bruno Amati & Jaromir Vlach

doi:10.1038/12087


Calcium–myristoyl switches turn on new lights ppE93 - E95

Tobias Meyer & John D. York

doi:10.1038/12090


Vessels vivified by Akt acting on NO synthase ppE95 - E96

Solomon H. Snyder & Samie R. Jaffrey

doi:10.1038/12093



AAA-ATPases at the crossroads of protein life and death ppE97 - E98

Peter Zwickl & Wolfgang Baumeister

doi:10.1038/12097


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Historical Perspective

Mapping the cell: advent of the thin section and characterization of the ER ppE99 - E101

Nicolas Rasmussen

doi:10.1038/12100


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Review

Fate maps old and new ppE103 - E109

Jonathan D.W. Clarke & Cheryll Tickle

doi:10.1038/12105


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Articles

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 pp193 - 199

Andrea C. Carrano, Esther Eytan, Avram Hershko & Michele Pagano

doi:10.1038/12013

See also: News and Views by Amati & Vlach


Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src pp200 - 206

Dan P. Felsenfeld, Pamela L. Schwartzberg, Ana Venegas, Richard Tse & Michael P. Sheetz

doi:10.1038/12021

See also: News and Views by Vuori & Ruoslahti


p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells pp207 - 214

Hedwig Sutterlüty, Eric Chatelain, Alain Marti, Christiane Wirbelauer, Matthias Senften, Uli Müller & Wilhelm Krek

doi:10.1038/12027

See also: News and Views by Amati & Vlach


Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies pp215 - 220

R. Mark Grady, Robert W. Grange, Kim S. Lau, Margaret M. Maimone, Mia C. Nichol, James T. Stull & Joshua R. Sanes

doi:10.1038/12034

See also: News and Views by Bredt


The base of the proteasome regulatory particle exhibits chaperone-like activity pp221 - 226

Beate C. Braun, Michael Glickman, Regine Kraft, Burkhardt Dahlmann, Peter-M. Kloetzel, Daniel Finley & Marion Schmidt

doi:10.1038/12043

See also: News and Views by Zwickl & Baumeister


Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappaB loop pp227 - 233

Bodo Levkau, Marta Scatena, Cecilia M. Giachelli, Russell Ross & Elaine W. Raines

doi:10.1038/12050


Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase pp234 - 241

Kristin B. Hendricks, Bo Qing Wang, Elisabeth A. Schnieders & Jeremy Thorner

doi:10.1038/12058

See also: News and Views by Meyer & York


Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading pp242 - 248

Frank N. van Leeuwen, Sanne van Delft, Hendrie E. Kain, Rob A. van der Kammen & John G. Collard

doi:10.1038/12068


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Brief Communication

Phosphatidylinositol-3-OH kinases are Rab5 effectors pp249 - 252

Savvas Christoforidis, Marta Miaczynska, Keith Ashman, Matthias Wilm, Liyun Zhao, Shu-Chin Yip, Michael D. Waterfield, Jonathan M. Backer & Marino Zerial

doi:10.1038/12075


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