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Nature Cell Biology 1, E97–E98 (1 August 1999) | doi:10.1038/12097

AAA-ATPases at the crossroads of protein life and death

Peter Zwickl & Wolfgang Baumeister

The base subcomplex of the yeast 26S proteasome can refold a denatured protein in vitro, a function opposite to its presumed role in protein degradation. Can this paradox be resolved?