Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vessels vivified by Akt acting on NO synthase

Nature Cell Biology volume 1, pages E95–E96 (1999)Cite this article

Abstract

The short- and long-term effects of stimuli such as shear stress on blood vessels are mediated through endothelial nitric oxide synthase. But whereas the short-term effects occur through transient increases in cytosolic calcium, the long-term changes result from constitutive activation of the synthase by the serine/threonine kinase Akt.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Production of nitric oxide (NO) is usually thought to be triggered by the increases in cytosolic calcium (Ca2+) that occur following the stimulation of receptors for molecules such as acetylcholine and bradykinin.

References

  1. Fulton, D. et al. Nature 399, 597–601 (1999).

    Article  CAS  Google Scholar 

  2. Dimmeler, S. et al. Nature 399, 601–605 (1999).

    Article  CAS  Google Scholar 

  3. Busse, R. & Fleming, I. J. Vasc. Res. 35, 73–84 (1998).

    Article  CAS  Google Scholar 

  4. Dimmeler, S. et al. Circ. Res. 83, 334–341 (1998).

    Article  CAS  Google Scholar 

  5. Shaul, P. W. et al. J. Biol. Chem. 271, 6518–6522 (1996).

    Article  CAS  Google Scholar 

  6. Garcia-Cardena, G. et al. Proc. Natl Acad. Sci. USA 93, 6448–6453 (1996).

    Article  CAS  Google Scholar 

  7. Michel, J. B., Feron, O., Sacks, D. & Michel, T. J. Biol. Chem. 272, 15583–15586 (1997).

    Article  CAS  Google Scholar 

  8. Garcia-Cardena, G. et al. J. Biol. Chem. 272, 25437–25440 (1997).

    Article  CAS  Google Scholar 

  9. Von der Leyen, H. E., Mann, M. J. & Dzau, V. J. Semin. Interv. Cardiol. 1, 209–214 (1996).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neuroscience, The Johns Hopkins University School of Medicine, Pharmacology and Molecular Sciences, and Psychiatry, 725 N. Wolfe Street, Baltimore, 21205, Maryland, USA

    Solomon H. Snyder & Samie R. Jaffrey

Authors
  1. Solomon H. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samie R. Jaffrey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Solomon H. Snyder.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Snyder, S., Jaffrey, S. Vessels vivified by Akt acting on NO synthase. Nat Cell Biol 1, E95–E96 (1999). https://doi.org/10.1038/12093

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/12093

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing