News and Views abstract
Nature Cell Biology 1, E95 - E96 (1999)
doi:10.1038/12093
Vessels vivified by Akt acting on NO synthase
Solomon H. Snyder1 & Samie R. Jaffrey1
- Solomon H. Snyder and Samie R. Jaffrey are at The Johns Hopkins University School of Medicine, Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.
Correspondence to: Solomon H. Snyder1 e-mail: ssnyder@bs.jhmi.edu
Abstract
The short- and long-term effects of stimuli such as shear stress on blood vessels are mediated through endothelial nitric oxide synthase. But whereas the short-term effects occur through transient increases in cytosolic calcium, the long-term changes result from constitutive activation of the synthase by the serine/threonine kinase Akt.
