News and Views abstract
Nature Cell Biology 1, E91 - E93 (1999)
doi:10.1038/12087
Kip1 meets SKP2: new links in cell-cycle control
- Bruno Amati and Jaromir Vlach are at the Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland.
Correspondence to: Bruno Amati1 e-mail: bruno.amati@isrec.unil.ch
Abstract
The cyclin-dependent kinase inhibitor p27Kip1 is degraded in a phosphorylation- and ubiquitin-dependent way upon cell-cycle entry. p45SKP2, the adaptor subunit of the ubiquitin–protein ligase SCFSKP2, may mediate recognition and ubiquitination of phosphorylated p27Kip1.
