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Nature Cell Biology 1, E35–E37 (1 June 1999) | doi:10.1038/10028

Caveolin, cholesterol and Ras signalling

Paul W. Sternberg & Sandra L. Schmid

Studies on the role of cholesterol- and caveolin-rich membrane microdomains in localizing Ras to the plasma membrane and enabling its signalling activity reveal intriguing differences both between mammalian H-Ras and K-Ras and between requirements for Ras signalling in mammalian and nematode cells.