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Nature Cell Biology 1, E37–E38 (1 June 1999) | doi:10.1038/10030
Cholesterol: stuck in traffic
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Abstract
Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.
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