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Article
Nature Cell Biology 1, 88–93 (1 June 1999) | doi:10.1038/10054
Centrosome duplication in mammalian somatic cells requires E2F and Cdk2|[ndash]|Cyclin A
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Abstract
Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2–cyclin A activity.
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