Figure 1 - Is TAP a global mRNA export factor?


From the following article

TAPping into transport

Caterina Strambio de Castillia & Michael P. Rout

Nature Cell Biology 1, E31 - E33 (1999)

doi:10.1038/10024

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TAP recognizes the constitutive transport element (CTE) sequence present in retroviral RNAs and mediates their export from the nucleus in a largely unknown manner. TAP appears to be independent of the action of known nuclear transport factors and to interact directly with nuclear-pore complexes (NPCs). TAP binds to p15, which could cooperate with TAP to promote CTE binding and NPC association. TAP also binds to cellular mRNA. Moreover, TAP is the closest human relative of the yeast protein Mex67, which is implicated in mRNA export. In the model proposed, TAP interacts with cellular mRNAs and effects their translocation through the NPC by a mechanism similar to the one used by TAP to export viral RNAs.

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