News and Views abstract
Nature Cell Biology 1, E37 - E38 (1999)
doi:10.1038/10030
Cholesterol: stuck in traffic
Sushmita Mukherjee1 & Frederick R. Maxfield1
- Sushmita Mukherjee and Frederick R. Maxfield are at the Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021 , USA.
Correspondence to: Frederick R. Maxfield1 e-mail: frmaxfie@mail.med.cornell.edu
Abstract
Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.
