Nature Cell Biology
1, E35 - E37 (1999)
doi:10.1038/10028
Caveolin, cholesterol and Ras signalling Paul W. Sternberg1
& Sandra L. Schmid21
Paul W. Sternberg is in the Department of Biology,
California Institute of Technology, 1201 East California Blvd
, Pasadena, California 91125,
USA. 2
Sandra L. Schmid is at the Scripps Research Institute
, 10550 N. Torrey Pines, La Jolla,
California 92037, USA.
Correspondence should be addressed to Paul W. Sternberg sternbergp@starbase1.caltech.eduStudies on the role of cholesterol- and caveolin-rich membrane microdomains
in localizing Ras to the plasma membrane and enabling its signalling activity
reveal intriguing differences both between mammalian H-Ras and K-Ras and between
requirements for Ras signalling in mammalian and nematode cells.
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