News and Views abstract
Nature Cell Biology 1, E35 - E37 (1999)
doi:10.1038/10028
Caveolin, cholesterol and Ras signalling
Paul W. Sternberg1 & Sandra L. Schmid2
- Paul W. Sternberg is in the Department of Biology, California Institute of Technology, 1201 East California Blvd , Pasadena, California 91125, USA.
- Sandra L. Schmid is at the Scripps Research Institute , 10550 N. Torrey Pines, La Jolla, California 92037, USA.
Correspondence to: Paul W. Sternberg1 e-mail: sternbergp@starbase1.caltech.edu
Abstract
Studies on the role of cholesterol- and caveolin-rich membrane microdomains in localizing Ras to the plasma membrane and enabling its signalling activity reveal intriguing differences both between mammalian H-Ras and K-Ras and between requirements for Ras signalling in mammalian and nematode cells.
