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Nature Cell Biology  1, E35 - E37 (1999)
doi:10.1038/10028

Caveolin, cholesterol and Ras signalling

Paul W. Sternberg1 & Sandra L. Schmid2

1  Paul W. Sternberg is in the Department of Biology, California Institute of Technology, 1201 East California Blvd , Pasadena, California 91125, USA.

2  Sandra L. Schmid is at the Scripps Research Institute , 10550 N. Torrey Pines, La Jolla, California 92037, USA.

Correspondence should be addressed to Paul W. Sternberg sternbergp@starbase1.caltech.edu
Studies on the role of cholesterol- and caveolin-rich membrane microdomains in localizing Ras to the plasma membrane and enabling its signalling activity reveal intriguing differences both between mammalian H-Ras and K-Ras and between requirements for Ras signalling in mammalian and nematode cells.

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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