J. Wade Harper is at the Verna and Marrs McLean Department of Biochemistry, and Stephen J. Elledge is at the Howard Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.
F-box proteins act as specificity factors for the ubiquitination, and thus
degradation, of target proteins. New results point to the importance of F-box
proteins in controlling the transcriptional programs that regulate development
and the cell cycle.
