News and Views abstract
Nature Cell Biology 1, E5 - E7 (1999)
doi:10.1038/8952
Skipping into the E2F1-destruction pathway
J. Wade Harper1 & Stephen J. Elledge1
- J. Wade Harper is at the Verna and Marrs McLean Department of Biochemistry, and Stephen J. Elledge is at the Howard Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.
Correspondence to: J. Wade Harper1 e-mail: jharper@bcm.tmc.edu
Abstract
F-box proteins act as specificity factors for the ubiquitination, and thus degradation, of target proteins. New results point to the importance of F-box proteins in controlling the transcriptional programs that regulate development and the cell cycle.
