Nature Cell Biology
1, E17 - E22 (1999)
doi:10.1038/8967
Transport-vesicle targeting: tethers before SNAREsSuzanne R. Pfeffer
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA
Protein secretion and the transport of proteins between membrane-bound
compartments are mediated by small, membrane-bound vesicles. Here I review
what is known about the process by which vesicles are targeted to the correct
destination. A growing family of proteins, whose precise modes of action are
far from established, is involved in targeting. Despite the wide diversity
in the identities of the players, some common themes are emerging that may
explain how vesicles can identify their targets and release their cargo at
the correct time and place in eukaryotic cells.
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