News and Views abstract
Nature Cell Biology 1, E10 - E11 (1999)
doi:10.1038/8960
What goes up must come down
Sally J. Leevers1
- Sally J. Leevers is in the Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 5BT, UK, and is at the University College London branch of the Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, UK.
Correspondence to: Sally J. Leevers1 e-mail: sallyl@ludwig.ucl.ac.uk
Abstract
The activity of the epidermal-growth-factor receptor is highly regulated during Drosophila development. Two negative-feedback loops involving the proteins Kekkon1 and Sprouty have been found to act by quite different inhibitory mechanisms.
