Browse Articles

  • Editorial |

    Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report.

  • Article |

    Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.

    • Evangelos Giampazolias
    • , Barbara Zunino
    • , Sandeep Dhayade
    • , Florian Bock
    • , Catherine Cloix
    • , Kai Cao
    • , Alba Roca
    • , Jonathan Lopez
    • , Gabriel Ichim
    • , Emma Proïcs
    • , Camila Rubio-Patiño
    • , Loic Fort
    • , Nader Yatim
    • , Emma Woodham
    • , Susana Orozco
    • , Lucia Taraborrelli
    • , Nieves Peltzer
    • , Daniele Lecis
    • , Laura Machesky
    • , Henning Walczak
    • , Matthew L. Albert
    • , Simon Milling
    • , Andrew Oberst
    • , Jean-Ehrland Ricci
    • , Kevin M. Ryan
    • , Karen Blyth
    •  & Stephen W. G. Tait
  • Article |

    Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels.

    • Maria Skamagki
    • , Cristina Correia
    • , Percy Yeung
    • , Timour Baslan
    • , Samuel Beck
    • , Cheng Zhang
    • , Christian A. Ross
    • , Lam Dang
    • , Zhong Liu
    • , Simona Giunta
    • , Tzu-Pei Chang
    • , Joye Wang
    • , Aparna Ananthanarayanan
    • , Martina Bohndorf
    • , Benedikt Bosbach
    • , James Adjaye
    • , Hironori Funabiki
    • , Jonghwan Kim
    • , Scott Lowe
    • , James J. Collins
    • , Chi-Wei Lu
    • , Hu Li
    • , Rui Zhao
    •  & Kitai Kim
  • Article |

    Shi et al. map the ciliary transition zone by STORM imaging, characterizing protein arrangements in nested rings and finding that mutations in RPGRIP1L that are associated with the ciliopathy Joubert syndrome disrupt SMO ciliary localization.

    • Xiaoyu Shi
    • , Galo Garcia III
    • , Julie C. Van De Weghe
    • , Ryan McGorty
    • , Gregory J. Pazour
    • , Dan Doherty
    • , Bo Huang
    •  & Jeremy F. Reiter
  • Article |

    Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.

    • Ceniz Zihni
    • , Evi Vlassaks
    • , Stephen Terry
    • , Jeremy Carlton
    • , Thomas King Chor Leung
    • , Michael Olson
    • , Franck Pichaud
    • , Maria Susana Balda
    •  & Karl Matter
  • Article |

    Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.

    • Stephanie Andrea Schalbetter
    • , Anton Goloborodko
    • , Geoffrey Fudenberg
    • , Jon-Matthew Belton
    • , Catrina Miles
    • , Miao Yu
    • , Job Dekker
    • , Leonid Mirny
    •  & Jonathan Baxter
  • Article |

    Grelet et al. find that hnRNP E1 release from PNUTS pre-RNA in response to TGFβ generates a lncRNA that acts as competitive sponge for miR-205, promoting epithelial–mesenchymal transition in cancer.

    • Simon Grelet
    • , Laura A. Link
    • , Breege Howley
    • , Clémence Obellianne
    • , Viswanathan Palanisamy
    • , Vamsi K. Gangaraju
    • , J. Alan Diehl
    •  & Philip H. Howe
  • Article |

    Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.

    • Sarah J. Horton
    • , George Giotopoulos
    • , Haiyang Yun
    • , Shabana Vohra
    • , Olivia Sheppard
    • , Rachael Bashford-Rogers
    • , Mamunur Rashid
    • , Alexandra Clipson
    • , Wai-In Chan
    • , Daniel Sasca
    • , Loukia Yiangou
    • , Hikari Osaki
    • , Faisal Basheer
    • , Paolo Gallipoli
    • , Natalie Burrows
    • , Ayşegül Erdem
    • , Anastasiya Sybirna
    • , Sarah Foerster
    • , Wanfeng Zhao
    • , Tonci Sustic
    • , Anna Petrunkina Harrison
    • , Elisa Laurenti
    • , Jessica Okosun
    • , Daniel Hodson
    • , Penny Wright
    • , Ken G. Smith
    • , Patrick Maxwell
    • , Jude Fitzgibbon
    • , Ming Q. Du
    • , David J. Adams
    •  & Brian J. P. Huntly
  • Article |

    Hiraike et al. identify nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat. NFIA activates cell-type-specific enhancers prior to differentiation and facilitates PPARγ binding to regulate the brown fat gene program.

    • Yuta Hiraike
    • , Hironori Waki
    • , Jing Yu
    • , Masahiro Nakamura
    • , Kana Miyake
    • , Gaku Nagano
    • , Ryo Nakaki
    • , Ken Suzuki
    • , Hirofumi Kobayashi
    • , Shogo Yamamoto
    • , Wei Sun
    • , Tomohisa Aoyama
    • , Yusuke Hirota
    • , Haruya Ohno
    • , Kenji Oki
    • , Masayasu Yoneda
    • , Andrew P. White
    • , Yu-Hua Tseng
    • , Aaron M. Cypess
    • , Therese J. Larsen
    • , Naja Z. Jespersen
    • , Camilla Scheele
    • , Shuichi Tsutsumi
    • , Hiroyuki Aburatani
    • , Toshimasa Yamauchi
    •  & Takashi Kadowaki
  • Article |

    Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

    • Aimee Flores
    • , John Schell
    • , Abigail S. Krall
    • , David Jelinek
    • , Matilde Miranda
    • , Melina Grigorian
    • , Daniel Braas
    • , Andrew C. White
    • , Jessica L. Zhou
    • , Nicholas A. Graham
    • , Thomas Graeber
    • , Pankaj Seth
    • , Denis Evseenko
    • , Hilary A. Coller
    • , Jared Rutter
    • , Heather R. Christofk
    •  & William E. Lowry
  • Article |

    Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.

    • John C. Schell
    • , Dona R. Wisidagama
    • , Claire Bensard
    • , Helong Zhao
    • , Peng Wei
    • , Jason Tanner
    • , Aimee Flores
    • , Jeffrey Mohlman
    • , Lise K. Sorensen
    • , Christian S. Earl
    • , Kristofor A. Olson
    • , Ren Miao
    • , T. Cameron Waller
    • , Don Delker
    • , Priyanka Kanth
    • , Lei Jiang
    • , Ralph J. DeBerardinis
    • , Mary P. Bronner
    • , Dean Y. Li
    • , James E. Cox
    • , Heather R. Christofk
    • , William E. Lowry
    • , Carl S. Thummel
    •  & Jared Rutter
  • Article |

    Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence.

    • Selene Glück
    • , Baptiste Guey
    • , Muhammet Fatih Gulen
    • , Katharina Wolter
    • , Tae-Won Kang
    • , Niklas Arndt Schmacke
    • , Anne Bridgeman
    • , Jan Rehwinkel
    • , Lars Zender
    •  & Andrea Ablasser
  • News and Views |

    CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

    • Ivan Krivega
    •  & Ann Dean
  • News and Views |

    Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.

    • Lucia Altucci
  • Letter |

    Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth.

    • Kimberly C. Lin
    • , Toshiro Moroishi
    • , Zhipeng Meng
    • , Han-Sol Jeong
    • , Steven W. Plouffe
    • , Yoshitaka Sekido
    • , Jiahuai Han
    • , Hyun Woo Park
    •  & Kun-Liang Guan
  • News and Views |

    Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss.

    • Jaclyn Sceneay
    •  & Sandra S. McAllister
  • News and Views |

    The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value.

    • Jichao Chen
  • Article |

    Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration.

    • Ying Xi
    • , Thomas Kim
    • , Alexis N. Brumwell
    • , Ian H. Driver
    • , Ying Wei
    • , Victor Tan
    • , Julia R. Jackson
    • , Jianming Xu
    • , Dong-Kee Lee
    • , Jeffrey E. Gotts
    • , Michael A. Matthay
    • , John M. Shannon
    • , Harold A. Chapman
    •  & Andrew E. Vaughan
  • Article |

    Joyce and colleagues report that obesity promotes lung neutrophilia in mice, which in the presence of a primary breast tumour fosters metastasis to the lung in a manner dependent on GM-CSF and IL5.

    • Daniela F. Quail
    • , Oakley C. Olson
    • , Priya Bhardwaj
    • , Logan A. Walsh
    • , Leila Akkari
    • , Marsha L. Quick
    • , I-Chun Chen
    • , Nils Wendel
    • , Nir Ben-Chetrit
    • , Jeanne Walker
    • , Peter R. Holt
    • , Andrew J. Dannenberg
    •  & Johanna A. Joyce
  • Article |

    Bitler et al. show that HDAC6 activity is essential for the survival of ovarian cancer cells carrying loss-of-function ARID1A mutation, thus representing a promising therapeutic target.

    • Benjamin G. Bitler
    • , Shuai Wu
    • , Pyoung Hwa Park
    • , Yang Hai
    • , Katherine M. Aird
    • , Yemin Wang
    • , Yali Zhai
    • , Andrew V. Kossenkov
    • , Ana Vara-Ailor
    • , Frank J. Rauscher III
    • , Weiping Zou
    • , David W. Speicher
    • , David G. Huntsman
    • , Jose R. Conejo-Garcia
    • , Kathleen R. Cho
    • , David W. Christianson
    •  & Rugang Zhang
  • Article |

    Hanssen et al. show that CTCF–cohesin binding sites at the α-globin gene cluster function as boundaries to restrict the interaction of enhancers with the flanking chromatin, thus preventing abnormal gene expression.

    • Lars L. P. Hanssen
    • , Mira T. Kassouf
    • , A. Marieke Oudelaar
    • , Daniel Biggs
    • , Chris Preece
    • , Damien J. Downes
    • , Matthew Gosden
    • , Jacqueline A. Sharpe
    • , Jacqueline A. Sloane-Stanley
    • , Jim R. Hughes
    • , Benjamin Davies
    •  & Douglas R. Higgs