MRC Laboratory of Molecular Biology

Of stem cells and ethics

Latest Research

  • Article |

    PERK regulates tumour cell survival. Bu et al. show that the unfolded protein response protein PERK induces miR-211 repression of the circadian factor Bmal1 to regulate protein synthesis and stress responses, contributing to tumour progression.

    • Yiwen Bu
    • , Akihiro Yoshida
    • , Nilesh Chitnis
    • , Brian J. Altman
    • , Feven Tameire
    • , Amanda Oran
    • , Victoria Gennaro
    • , Kent E. Armeson
    • , Steven B. McMahon
    • , Gerald B. Wertheim
    • , Chi V. Dang
    • , Davide Ruggero
    • , Constantinos Koumenis
    • , Serge Y. Fuchs
    •  & J. Alan Diehl
  • Letter |

    Glycogen metabolism controls memory T cells. Ma et al. show that the metabolic gene PCK1 promotes glycogen formation, which is used in the pentose phosphate pathway, generating glutathione that is important for counteraction of ROS and thus promotion of memory T-cell maintenance, and resulting in improved antitumour immunity.

    • Ruihua Ma
    • , Tiantian Ji
    • , Huafeng Zhang
    • , Wenqian Dong
    • , Xinfeng Chen
    • , Pingwei Xu
    • , Degao Chen
    • , Xiaoyu Liang
    • , Xiaonan Yin
    • , Yuying Liu
    • , Jingwei Ma
    • , Ke Tang
    • , Yi Zhang
    • , Yue’e Peng
    • , Jinzhi Lu
    • , Yi Zhang
    • , Xiaofeng Qin
    • , Xuetao Cao
    • , Yonghong Wan
    •  & Bo Huang
  • Article |

    Mechanics of epidermal differentiation Miroshnikova et al. find that during embryonic development, epidermal basal layer crowding generates local changes in cell shape, cortical tension, and adhesion that initiate differentiation and delamination

    • Yekaterina A. Miroshnikova
    • , Huy Q. Le
    • , David Schneider
    • , Torsten Thalheim
    • , Matthias Rübsam
    • , Nadine Bremicker
    • , Julien Polleux
    • , Nadine Kamprad
    • , Marco Tarantola
    • , Irène Wang
    • , Martial Balland
    • , Carien M. Niessen
    • , Joerg Galle
    •  & Sara A. Wickström
  • Article |

    Dziedzic et al. show that the ubiquitin-binding protein ABIN-1 is recruited into TNFR1 signalling complex in a manner dependent on Met1 -ubiquitinating complex LUBAC to regulate K63 de-ubiquitination to activate RIPK1.

    • Slawomir A. Dziedzic
    • , Zhenyi Su
    • , Vica Jean Barrett
    • , Ayaz Najafov
    • , Adnan K. Mookhtiar
    • , Palak Amin
    • , Heling Pan
    • , Li Sun
    • , Hong Zhu
    • , Averil Ma
    • , Derek W. Abbott
    •  & Junying Yuan

News & Comment

  • Editorial |

    Advances in stem cell research offer unprecedented insights into human biology and opportunities for clinical translation. They also raise many questions with social and ethical implications.

  • News and Views |

    Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.

    • Francesca Storici
    •  & Ailone E. Tichon
  • News and Views |

    Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi.

    • J. Christopher Fromme
    •  & Mary Munson
  • News and Views |

    After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit.

    • Henna M. Moore
    •  & Maria K. Vartiainen
  • News and Views |

    PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.

    • Katharina Schlacher
  • News and Views |

    Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.

    • Jeffrey W. Brown
    •  & Jason C. Mills

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