Cell plasticity in epithelial homeostasis and tumorigenesis

Latest Research

  • Article |

    Liu et al. find that PKM2 methylated by CARM1 inhibits Ca2+ influx from endoplasmic reticulum to mitochondria, thus restraining mitochondrial oxidative phosphorylation while promoting aerobic glycolysis and breast cancer growth.

    • Fabao Liu
    • , Fengfei Ma
    • , Yuyuan Wang
    • , Ling Hao
    • , Hao Zeng
    • , Chenxi Jia
    • , Yidan Wang
    • , Peng Liu
    • , Irene M. Ong
    • , Baobin Li
    • , Guojun Chen
    • , Jiaoyang Jiang
    • , Shaoqin Gong
    • , Lingjun Li
    •  & Wei Xu
  • Article |

    In the developing mouse pancreas, EGFR regulates apical polarity via PI(3)K and Rac1 and elicits different ligand-dependent effects: BTC enables β-cell commitment and EGF inhibits polarization of epithelial progenitors during the primary transition.

    • Zarah M. Löf-Öhlin
    • , Pia Nyeng
    • , Matthew E. Bechard
    • , Katja Hess
    • , Eric Bankaitis
    • , Thomas U. Greiner
    • , Jacqueline Ameri
    • , Christopher V. Wright
    •  & Henrik Semb
  • Article |

    Cruz-Acuña et al. develop synthetic hydrogels that support the generation and expansion of viable human intestinal organoids from pluripotent stem cells and can be used as injectable vehicles for organoid engraftment and wound healing.

    • Ricardo Cruz-Acuña
    • , Miguel Quirós
    • , Attila E. Farkas
    • , Priya H. Dedhia
    • , Sha Huang
    • , Dorothée Siuda
    • , Vicky García-Hernández
    • , Alyssa J. Miller
    • , Jason R. Spence
    • , Asma Nusrat
    •  & Andrés J. García
  • Article |

    Boyd et al. monitored the effects of patient-derived acute myeloid leukaemia (AML) cells on human HSPCs in vivo and found that AML impairs bone marrow adipocyte differentiation, and this in turn impedes healthy endogenous haematopoiesis.

    • Allison L. Boyd
    • , Jennifer C. Reid
    • , Kyle R. Salci
    • , Lili Aslostovar
    • , Yannick D. Benoit
    • , Zoya Shapovalova
    • , Mio Nakanishi
    • , Deanna P. Porras
    • , Mohammed Almakadi
    • , Clinton J. V. Campbell
    • , Michael F. Jackson
    • , Catherine A. Ross
    • , Ronan Foley
    • , Brian Leber
    • , David S. Allan
    • , Mitchell Sabloff
    • , Anargyros Xenocostas
    • , Tony J. Collins
    •  & Mickie Bhatia
  • Letter |

    Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 contributes to PARPi resistance in BRCA2-deficient tumours.

    • Beatrice Rondinelli
    • , Ewa Gogola
    • , Hatice Yücel
    • , Alexandra A. Duarte
    • , Marieke van de Ven
    • , Roxanne van der Sluijs
    • , Panagiotis A. Konstantinopoulos
    • , Jos Jonkers
    • , Raphaël Ceccaldi
    • , Sven Rottenberg
    •  & Alan D. D’Andrea

News & Comment

  • News and Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille
  • News and Views |

    It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress.

    • Jörg Höhfeld
  • News and Views |

    During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.

    • Jonathan N. Rosen
    •  & Mary K. Baylies
  • News and Views |

    Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.

    • Wei Zheng
    •  & Jeffrey W. Pollard
  • News and Views |

    The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.

    • Andrew Oberst

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