Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Latest Research

  • Article |

    Hervera et al. show that extracellular vesicles containing NOX2 complexes are released from macrophages and incorporated into injured axons, leading to axonal regeneration through PI3K–p-Akt signalling.

    • Arnau Hervera
    • , Francesco De Virgiliis
    • , Ilaria Palmisano
    • , Luming Zhou
    • , Elena Tantardini
    • , Guiping Kong
    • , Thomas Hutson
    • , Matt C. Danzi
    • , Rotem Ben-Tov Perry
    • , Celio X. C. Santos
    • , Alexander N. Kapustin
    • , Roland A. Fleck
    • , José Antonio Del Río
    • , Thomas Carroll
    • , Vance Lemmon
    • , John L. Bixby
    • , Ajay M. Shah
    • , Mike Fainzilber
    •  & Simone Di Giovanni
  • Article |

    Xie and colleagues find that activated mTORC1 growth signalling impairs DNA repair through S6K-mediated phosphorylation and inhibition of the RNF168 ligase.

    • Xiaoduo Xie
    • , Hongli Hu
    • , Xinyuan Tong
    • , Long Li
    • , Xiangyuan Liu
    • , Min Chen
    • , Huairui Yuan
    • , Xia Xie
    • , Qingrun Li
    • , Yuxue Zhang
    • , Huafang Ouyang
    • , Mengqi Wei
    • , Jing Huang
    • , Pengda Liu
    • , Wenjian Gan
    • , Yong Liu
    • , Anyong Xie
    • , Xiaoling Kuai
    • , Gung-Wei Chirn
    • , Hu Zhou
    • , Rong Zeng
    • , Ronggui Hu
    • , Jun Qin
    • , Fei-Long Meng
    • , Wenyi Wei
    • , Hongbin Ji
    •  & Daming Gao
  • Article |

    Zajac et al. show that in colorectal cancer, decreased TGF-β signalling promotes apical actomyosin contractility and collective apical budding of invading tumour spheres with inverted polarity that drive metastatic spread.

    • Olivier Zajac
    • , Joel Raingeaud
    • , Fotine Libanje
    • , Celine Lefebvre
    • , Dora Sabino
    • , Isabelle Martins
    • , Pétronille Roy
    • , Clara Benatar
    • , Charlotte Canet-Jourdan
    • , Paula Azorin
    • , Mélanie Polrot
    • , Patrick Gonin
    • , Salima Benbarche
    • , Sylvie Souquere
    • , Gerard Pierron
    • , Damien Nowak
    • , Ludovic Bigot
    • , Michel Ducreux
    • , David Malka
    • , Camille Lobry
    • , Jean-Yves Scoazec
    • , Clarisse Eveno
    • , Marc Pocard
    • , Jean-Luc Perfettini
    • , Dominique Elias
    • , Peggy Dartigues
    • , Diane Goéré
    •  & Fanny Jaulin
  • Technical Report |

    Mittasch et al. show that controlling cytoplasmic flow via focused-light-induced cytoplasmic streaming (FLUCS), a non-invasive technique, can be used to invert asymmetric cell division in Caenorhabditis elegans zygotes.

    • Matthäus Mittasch
    • , Peter Gross
    • , Michael Nestler
    • , Anatol W. Fritsch
    • , Christiane Iserman
    • , Mrityunjoy Kar
    • , Matthias Munder
    • , Axel Voigt
    • , Simon Alberti
    • , Stephan W. Grill
    •  & Moritz Kreysing
  • Article |

    van Haren et al. develop a tool to rapidly dissociate proteins from the growing end of microtubules through photo-induced disassembly of end-binding protein 1 (EB1), and find that this reduces microtubule growth and alters cell migration.

    • Jeffrey van Haren
    • , Rabab A. Charafeddine
    • , Andreas Ettinger
    • , Hui Wang
    • , Klaus M. Hahn
    •  & Torsten Wittmann

News & Comment

  • News & Views |

    Mitochondria contain their own circular mitochondrial DNA (mtDNA), which, over time, is subjected to mutations that may eventually result in functional defects. A study now describes genetic and metabolic selection processes during germ cell development that prevent accumulation of harmful mtDNA variants.

    • Di Chen
    •  & Amander T. Clark
  • Editorial |

    A strong relationship between mentor and mentee is a crucial part of the training and professional development of scientists. Here, we discuss the means of successful mentorship and debunk some myths surrounding mentoring.

  • News & Views |

    Intrinsic factors that regulate dormancy of disseminated tumour cells (DTCs) are predominantly unknown. Now, knockdown of MSK1 is shown to accelerate bone metastasis of luminal breast cancer cells. MSK1 acts through epigenetic mechanisms that enforce the luminal phenotype and promote steady-state maintenance of DTCs within bone.

    • Candice Alexandra Grzelak
    •  & Cyrus Michael Ghajar
  • News & Views |

    Elucidating regulation of mitochondrial mRNA translation will improve our understanding of mitochondrial function during homeostasis and disease. Ribonuclease EXD2 is now shown to be important for mitochondrial translation and oxidative phosphorylation, and its loss enhances ROS production, slows development and extends lifespan in flies.

    • Brian M. Zid
    •  & Pankaj Kapahi
  • News & Views |

    Selective autophagy is important for controlled degradation of cellular components. However, a selective autophagic degradation mechanism for ribosomes in mammals has remained unclear. A study now describes non-selective and selective ribosome degradation and a significant role for ‘bystander’ non-selective autophagy.

    • Christian Münch
    •  & Ivan Dikic
  • News & Views |

    The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.

    • Miguel Sanchez-Alvarez
    •  & Chris Bakal

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