Cell plasticity in epithelial homeostasis and tumorigenesis

Latest Research

  • Article |

    Boyd et al. monitored the effects of patient-derived acute myeloid leukaemia (AML) cells on human HSPCs in vivo and found that AML impairs bone marrow adipocyte differentiation, and this in turn impedes healthy endogenous haematopoiesis.

    • Allison L. Boyd
    • , Jennifer C. Reid
    • , Kyle R. Salci
    • , Lili Aslostovar
    • , Yannick D. Benoit
    • , Zoya Shapovalova
    • , Mio Nakanishi
    • , Deanna P. Porras
    • , Mohammed Almakadi
    • , Clinton J. V. Campbell
    • , Michael F. Jackson
    • , Catherine A. Ross
    • , Ronan Foley
    • , Brian Leber
    • , David S. Allan
    • , Mitchell Sabloff
    • , Anargyros Xenocostas
    • , Tony J. Collins
    •  & Mickie Bhatia
  • Letter |

    Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 contributes to PARPi resistance in BRCA2-deficient tumours.

    • Beatrice Rondinelli
    • , Ewa Gogola
    • , Hatice Yücel
    • , Alexandra A. Duarte
    • , Marieke van de Ven
    • , Roxanne van der Sluijs
    • , Panagiotis A. Konstantinopoulos
    • , Jos Jonkers
    • , Raphaël Ceccaldi
    • , Sven Rottenberg
    •  & Alan D. D’Andrea
  • Article |

    Gilot et al. have found that TYRP1 mRNA, in addition to coding for TYRP1 protein, can promote melanoma by sequestering the tumour suppressor miR-16, thus de-repressing the mRNA transcription of miR-16 target RAB17, which is involved in melanoma cell proliferation.

    • David Gilot
    • , Mélodie Migault
    • , Laura Bachelot
    • , Fabrice Journé
    • , Aljosja Rogiers
    • , Emmanuelle Donnou-Fournet
    • , Ariane Mogha
    • , Nicolas Mouchet
    • , Marie-Laure Pinel-Marie
    • , Bernard Mari
    • , Tristan Montier
    • , Sébastien Corre
    • , Arthur Gautron
    • , Florian Rambow
    • , Petra El Hajj
    • , Rania Ben Jouira
    • , Sophie Tartare-Deckert
    • , Jean-Christophe Marine
    • , Brice Felden
    • , Ghanem Ghanem
    •  & Marie-Dominique Galibert
  • Article |

    Wu et al. show that prosurvival BCL-2 proteins disrupt SUFU repression of GLI activity, leading to GLI target gene expression. BH3 mimetics disable GLI transcriptional activity driven by HH pathway mutations.

    • Xiaofeng Wu
    • , Li-shu Zhang
    • , Jason Toombs
    • , Yi-Chun Kuo
    • , John Tyler Piazza
    • , Rubina Tuladhar
    • , Quinn Barrett
    • , Chih-wei Fan
    • , Xuewu Zhang
    • , Loren D. Walensky
    • , Marcel Kool
    • , Steven Y. Cheng
    • , Rolf Brekken
    • , Joseph T. Opferman
    • , Douglas R. Green
    • , Tudor Moldoveanu
    •  & Lawrence Lum
  • Article |

    Anderson et al. show that LIF, ActA and Wnt support self-renewal in both pluripotent and endodermal cells. Upon removal of insulin, they induce differentiation of naive PSCs into extra-embryonic primitive endoderm and primed PSCs into definitive endoderm.

    • Kathryn G. V. Anderson
    • , William B. Hamilton
    • , Fabian V. Roske
    • , Ajuna Azad
    • , Teresa E. Knudsen
    • , Maurice A. Canham
    • , Lesley M. Forrester
    •  & Joshua M. Brickman

News & Comment

  • News and Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille
  • News and Views |

    It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress.

    • Jörg Höhfeld
  • News and Views |

    During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.

    • Jonathan N. Rosen
    •  & Mary K. Baylies
  • News and Views |

    Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.

    • Wei Zheng
    •  & Jeffrey W. Pollard
  • News and Views |

    The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.

    • Andrew Oberst

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