Nick Valmas and Steven Zuryn, University of Queensland

Our Series of Reviews on Autophagy is live – visit it here

Latest Research

  • Review Article |

    In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require ligand receptors and scaffold proteins for cargo specificity.

    • Damián Gatica
    • , Vikramjit Lahiri
    •  & Daniel J. Klionsky
  • Review Article |

    Autophagy and cancer: In this Review, Galluzzi and colleagues discuss the cellular and molecular mechanisms whereby autophagy functions in multiple aspects of malignant disease, including cancer initiation, progression and responses to therapy.

    • Marissa D. Rybstein
    • , José Manuel Bravo-San Pedro
    • , Guido Kroemer
    •  & Lorenzo Galluzzi
  • Article |

    Huang et al. identify IGF2BPs as an additional class of N6-methyladenosine (m6A) reader proteins. They find that IGF2BPs selectively bind to m6A-containing mRNAs and promote their stability.

    • Huilin Huang
    • , Hengyou Weng
    • , Wenju Sun
    • , Xi Qin
    • , Hailing Shi
    • , Huizhe Wu
    • , Boxuan Simen Zhao
    • , Ana Mesquita
    • , Chang Liu
    • , Celvie L. Yuan
    • , Yueh-Chiang Hu
    • , Stefan Hüttelmaier
    • , Jennifer R. Skibbe
    • , Rui Su
    • , Xiaolan Deng
    • , Lei Dong
    • , Miao Sun
    • , Chenying Li
    • , Sigrid Nachtergaele
    • , Yungui Wang
    • , Chao Hu
    • , Kyle Ferchen
    • , Kenneth D. Greis
    • , Xi Jiang
    • , Minjie Wei
    • , Lianghu Qu
    • , Jun-Lin Guan
    • , Chuan He
    • , Jianhua Yang
    •  & Jianjun Chen
  • Review Article |

    Mechanical forces influence both cytoplasmic and nuclear events. Kirby and Lammerding discuss recent evidence suggesting that the nucleus itself is a mechanosensor and methods to study nuclear mechanotransduction.

    • Tyler J. Kirby
    •  & Jan Lammerding
  • Article |

    Hawk et al. show that RIPK1 activation during extracellular matrix detachment induces mitophagy through mitochondrial phosphatase PGAM5 to increase reactive oxygen species and non-apoptotic cell death, and that antagonizing RIPK1/PGAM5 enhances tumour formation.

    • Mark A. Hawk
    • , Cassandra L. Gorsuch
    • , Patrick Fagan
    • , Chan Lee
    • , Sung Eun Kim
    • , Jens C. Hamann
    • , Joshua A. Mason
    • , Kelsey J. Weigel
    • , Matyas Abel Tsegaye
    • , Luqun Shen
    • , Sydney Shuff
    • , Junjun Zuo
    • , Stephan Hu
    • , Lei Jiang
    • , Sarah Chapman
    • , W. Matthew Leevy
    • , Ralph J. DeBerardinis
    • , Michael Overholtzer
    •  & Zachary T. Schafer
  • Resource |

    Lyden and colleagues use asymmetric flow field-flow fractionation to classify nanoparticles derived from cell lines and human samples, including previously uncharacterized large, Exo-L and small, Exo-S, exosome subsets.

    • Haiying Zhang
    • , Daniela Freitas
    • , Han Sang Kim
    • , Kristina Fabijanic
    • , Zhong Li
    • , Haiyan Chen
    • , Milica Tesic Mark
    • , Henrik Molina
    • , Alberto Benito Martin
    • , Linda Bojmar
    • , Justin Fang
    • , Sham Rampersaud
    • , Ayuko Hoshino
    • , Irina Matei
    • , Candia M. Kenific
    • , Miho Nakajima
    • , Anders Peter Mutvei
    • , Pasquale Sansone
    • , Weston Buehring
    • , Huajuan Wang
    • , Juan Pablo Jimenez
    • , Leona Cohen-Gould
    • , Navid Paknejad
    • , Matthew Brendel
    • , Katia Manova-Todorova
    • , Ana Magalhães
    • , José Alexandre Ferreira
    • , Hugo Osório
    • , André M. Silva
    • , Ashish Massey
    • , Juan R. Cubillos-Ruiz
    • , Giuseppe Galletti
    • , Paraskevi Giannakakou
    • , Ana Maria Cuervo
    • , John Blenis
    • , Robert Schwartz
    • , Mary Sue Brady
    • , Héctor Peinado
    • , Jacqueline Bromberg
    • , Hiroshi Matsui
    • , Celso A. Reis
    •  & David Lyden

News & Comment

  • News & Views |

    Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles, revealing a subtype without an encapsulating membrane and variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.

    • Andries Zijlstra
    •  & Dolores Di Vizio
  • News & Views |

    Cytoplasmic flows are essential for various cellular processes. However, tools to manipulate these flows within cells are still lacking. Now research shows that an optical tool allows for control of cytoplasmic flows and can be used as a subcellular rheometer.

    • Karsten Kruse
    • , Nicolas Chiaruttini
    •  & Aurélien Roux
  • News & Views |

    N6-methyladenosine (m6A) mRNA modification influences mRNA fate by stimulating recruitment of m6A reader proteins. A previously unappreciated class of m6A reader proteins is now shown to use a common RNA-binding domain and flanking regions to selectively bind m6A-containing mRNAs, increasing their translation and stability.

    • Katherine I. Zhou
    •  & Tao Pan

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