Berna Sozen, Gianluca Amadei and Magdalena-Zernicka-Goetz at the University of Cambridge

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Latest Research

  • Article |

    Nichols et al. identify an SHP2 inhibitor that disrupts SOS1-mediated RAS–GTP loading with demonstrated efficacy in various types of tumour driven by mutant BRAF, NF1 or RAS.

    • Robert J. Nichols
    • , Franziska Haderk
    • , Carlos Stahlhut
    • , Christopher J. Schulze
    • , Golzar Hemmati
    • , David Wildes
    • , Christos Tzitzilonis
    • , Kasia Mordec
    • , Abby Marquez
    • , Jason Romero
    • , Tientien Hsieh
    • , Aubhishek Zaman
    • , Victor Olivas
    • , Caroline McCoach
    • , Collin M. Blakely
    • , Zhengping Wang
    • , Gert Kiss
    • , Elena S. Koltun
    • , Adrian L. Gill
    • , Mallika Singh
    • , Mark A. Goldsmith
    • , Jacqueline A. M. Smith
    •  & Trever G. Bivona
  • Article |

    Almuedo-Castillo et al. show that extirpated embryos are reduced in size but exhibit normal proportions. Following a computational screen, the authors identify an increased concentration of the Nodal inhibitor Lefty to be responsible for the size scaling.

    • María Almuedo-Castillo
    • , Alexander Bläßle
    • , David Mörsdorf
    • , Luciano Marcon
    • , Gary H. Soh
    • , Katherine W. Rogers
    • , Alexander F. Schier
    •  & Patrick Müller
  • Letter |

    Chan Wah Hak et al. show how plasma membrane patches are primed for fast endophilin-mediated endocytosis and disassembly, in the absence of receptor stimulation, through FBP17 and CIP4 binding to SHIP2 and lamellipodin.

    • Laura Chan Wah Hak
    • , Shaheen Khan
    • , Ilaria Di Meglio
    • , Ah-Lai Law
    • , Safa Lucken-Ardjomande Häsler
    • , Leonor M. Quintaneiro
    • , Antonio P. A. Ferreira
    • , Matthias Krause
    • , Harvey T. McMahon
    •  & Emmanuel Boucrot
  • Article |

    Madaro et al. show that denervation induces accumulation of IL-6–STAT3-activated fibro-adipogenic progenitors without inflammation or muscle regeneration, leading to muscle atrophy and fibrosis.

    • Luca Madaro
    • , Magda Passafaro
    • , David Sala
    • , Usue Etxaniz
    • , Francesca Lugarini
    • , Daisy Proietti
    • , Maria Vittoria Alfonsi
    • , Chiara Nicoletti
    • , Sole Gatto
    • , Marco De Bardi
    • , Ricardo Rojas-García
    • , Lorenzo Giordani
    • , Sara Marinelli
    • , Vittoria Pagliarini
    • , Claudio Sette
    • , Alessandra Sacco
    •  & Pier Lorenzo Puri
  • Review Article |

    Stefano Piccolo and co-authors review recent insights into how YAP and TAZ transcription factors respond to the tissue environment, and how they mediate altered cell behaviour. Feedback mechanisms and crosstalk with other pathways are discussed, as are outstanding questions in the field.

    • Antonio Totaro
    • , Tito Panciera
    •  & Stefano Piccolo

News & Comment

  • News & Views |

    During embryo development, concentration gradients of signalling molecules instruct formation of different cell types. How these gradients adapt to variable embryo sizes to form a properly scaled individual remains elusive. A simple system of an activator and an inhibitor, with different diffusion properties, may give an answer.

    • Laurence Garric
    •  & Jeroen Bakkers
  • Editorial |

    Understanding the dynamics and complexity of tumour metastasis is crucial for improving clinical interventions and care for cancer patients. In this issue, we present the first of a Series of commissioned Review articles that discuss emerging concepts, technological advances and therapeutic implications in this exciting field.

  • News & Views |

    A previously unidentified protein complex termed Shieldin acts with the nucleosome-binding protein 53BP1 to limit end resection at DNA double-strand breaks, impacting myriad biological outcomes, from immunology to cancer therapy, and highlighting the importance of chromatin responses to DNA damage in vertebrates.

    • Roger A Greenberg
  • News & Views |

    Skeletal muscle denervation leads to myofibre atrophy with fibrosis and fatty infiltration of muscle-resident fibroadipogenic progenitors (FAPs). A study shows that on denervation, FAPs activate pathogenic STAT3–IL-6 signalling. Inhibition of this pathway prevents atrophy and points to potential therapeutic targets.

    • Giovanna Marazzi
    •  & David Sassoon
  • News & Views |

    Metastatic colonization of distant organs is the prime cause of mortality from cancer, and is governed by a series of steps that include survival and growth in the perivascular niche. A study now shows that L1CAM is necessary for tight physical interactions in this niche, involving a YAP–MRTF–β1-integrin mechanotransduction pathway.

    • Matthia A. Karreman
    •  & Frank Winkler
  • News & Views |

    Enteroendocrine (EE) cells secrete diverse peptide hormones, regulating food intake, digestion and metabolism. A study now challenges the traditional view that each hormone is the dominant product of a distinct EE cell type, showing that in response to local cues the same cell produces different hormones in different tissue compartments.

    • Ramesh A. Shivdasani

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