Cyrus Ghajar, Fred Hutchinson Cancer Research Center

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Latest Research

  • Letter |

    Kraft et al. show that chromosomal inversions that relocate a limb enhancer can establish asymmetric stripes of the enhancer with downstream genes, resulting in ectopic gene expression and limb phenotypes.

    • Katerina Kraft
    • , Andreas Magg
    • , Verena Heinrich
    • , Christina Riemenschneider
    • , Robert Schöpflin
    • , Julia Markowski
    • , Daniel M. Ibrahim
    • , Rocío Acuna-Hidalgo
    • , Alexandra Despang
    • , Guillaume Andrey
    • , Lars Wittler
    • , Bernd Timmermann
    • , Martin Vingron
    •  & Stefan Mundlos
  • Article |

    Moro et al. discover an Argonaute 2 (Ago2)-dependent miRNA network that, in response to substrate stiffness, regulates genes involved in tissue mechanics, and show that Ago2 restrains stiffness and contributes to regeneration in the zebrafish fin fold.

    • Albertomaria Moro
    • , Tristan P. Driscoll
    • , Liana C. Boraas
    • , William Armero
    • , Dionna M. Kasper
    • , Nicolas Baeyens
    • , Charlene Jouy
    • , Venkatesh Mallikarjun
    • , Joe Swift
    • , Sang Joon Ahn
    • , Donghoon Lee
    • , Jing Zhang
    • , Mengting Gu
    • , Mark Gerstein
    • , Martin Schwartz
    •  & Stefania Nicoli
  • Article |

    Romani et al. identify a response to reduced actomyosin contractility involving inhibition of Lipin-1, accumulation of SREBP transcription factors at the Golgi apparatus and activation of SREBP transcription driving increased lipid synthesis.

    • Patrizia Romani
    • , Irene Brian
    • , Giulia Santinon
    • , Arianna Pocaterra
    • , Matteo Audano
    • , Silvia Pedretti
    • , Samuel Mathieu
    • , Mattia Forcato
    • , Silvio Bicciato
    • , Jean-Baptiste Manneville
    • , Nico Mitro
    •  & Sirio Dupont
  • Technical Report |

    Nair et al. report the generation of human ESC-derived mature and functional β cells in vitro with a culture system including a step to induce clustering of immature β-like cells.

    • Gopika G. Nair
    • , Jennifer S. Liu
    • , Holger A. Russ
    • , Stella Tran
    • , Michael S. Saxton
    • , Richard Chen
    • , Charity Juang
    • , Mei-lan Li
    • , Vinh Q. Nguyen
    • , Simone Giacometti
    • , Sapna Puri
    • , Yuan Xing
    • , Yong Wang
    • , Gregory L. Szot
    • , Jose Oberholzer
    • , Anil Bhushan
    •  & Matthias Hebrok
  • Article |

    Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

    • Guihua Wang
    • , Jie Long
    • , Yuan Gao
    • , Weina Zhang
    • , Fei Han
    • , Chuan Xu
    • , Li Sun
    • , Shun-Chin Yang
    • , Jingqin Lan
    • , Zhenlin Hou
    • , Zhen Cai
    • , Guoxiang Jin
    • , Che-Chia Hsu
    • , Yu-Hui Wang
    • , Junbo Hu
    • , Tsai-Yu Chen
    • , Hongyu Li
    • , Min Gyu Lee
    •  & Hui-Kuan Lin
  • Article |

    Guo et al. identify SETDB1 and KDM4B as the methyltransferase and demethylase, respectively, for AKT. AKT methylation promotes its kinase activity and the subsequent tumorigenesis.

    • Jianping Guo
    • , Xiangpeng Dai
    • , Benoit Laurent
    • , Nana Zheng
    • , Wenjian Gan
    • , Jian Zhang
    • , Ailan Guo
    • , Min Yuan
    • , Pengda Liu
    • , John M. Asara
    • , Alex Toker
    • , Yang Shi
    • , Pier Paolo Pandolfi
    •  & Wenyi Wei

News & Comment

  • News & Views |

    Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.

    • Manuel Théry
    •  & Mario Pende
  • News & Views |

    Patients with diabetes could benefit from cell-based insulin therapy, but the supply of human islet tissue is limited. A study now reports an approach in which human-pluripotent-stem-cell-derived islet β-cells are purified and re-aggregated to generate cells that more closely resemble mature human β-cells.

    • Hans E. Hohmeier
    • , Jie An
    •  & Christopher B. Newgard
  • Editorial |

    Science thrives on the free exchange of ideas and collaboration between diverse groups, with researcher mobility greatly accelerating progress. With isolationist rhetoric increasingly dominating the political discourse in many countries, it is important to recognize the value of migration in science.

  • News & Views |

    AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.

    • Amelia K. Luciano
    •  & David A. Guertin
  • News & Views |

    Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

    • Chih-Yung Lee
    •  & Geraldine Seydoux
  • News & Views |

    It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.

    • Melanie Werner-Klein
    •  & Christoph A. Klein

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