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Latest Research

  • Letter |

    Xin et al. track stem cells in live mice to show that fate determination is a flexible process during homeostatic hair follicle growth, and progenitor cells can change differentiation outcomes as a consequence of dynamic relocation.

    • Tianchi Xin
    • , David Gonzalez
    • , Panteleimon Rompolas
    •  & Valentina Greco
  • Article |

    Lafont et al. uncover a checkpoint mediated by TBK1 and IKKε, which phosphorylate RIPK1 in the TNFR1-SC. TBK1 and IKKε recruitment depends on M1 ubiquitylation and NEMO to restrict TNF-induced cell death.

    • Elodie Lafont
    • , Peter Draber
    • , Eva Rieser
    • , Matthias Reichert
    • , Sebastian Kupka
    • , Diego de Miguel
    • , Helena Draberova
    • , Anne von Mässenhausen
    • , Amandeep Bhamra
    • , Stephen Henderson
    • , Katarzyna Wojdyla
    • , Avigayil Chalk
    • , Silvia Surinova
    • , Andreas Linkermann
    •  & Henning Walczak
  • Letter |

    di Ronza et al. identify CLN8 as a cargo receptor for lysosomal enzymes required for their endoplasmic-reticulum-to-Golgi transport, linking Batten disease caused by CLN8 mutations to defects in organelle biogenesis.

    • Alberto di Ronza
    • , Lakshya Bajaj
    • , Jaiprakash Sharma
    • , Deepthi Sanagasetti
    • , Parisa Lotfi
    • , Carolyn Joy Adamski
    • , John Collette
    • , Michela Palmieri
    • , Abdallah Amawi
    • , Lauren Popp
    • , Kevin Tommy Chang
    • , Maria Chiara Meschini
    • , Hon-Chiu Eastwood Leung
    • , Laura Segatori
    • , Alessandro Simonati
    • , Richard Norman Sifers
    • , Filippo Maria Santorelli
    •  & Marco Sardiello
  • Article |

    Michel et al. report unique localization of non-canonical BAF to CTCF sites and promoters, which confers synthetic lethality in canonical BAF-perturbed synovial sarcoma and malignant rhabdoid tumour cells.

    • Brittany C. Michel
    • , Andrew R. D’Avino
    • , Seth H. Cassel
    • , Nazar Mashtalir
    • , Zachary M. McKenzie
    • , Matthew J. McBride
    • , Alfredo M. Valencia
    • , Qianhe Zhou
    • , Michael Bocker
    • , Luis M. M. Soares
    • , Joshua Pan
    • , David I. Remillard
    • , Caleb A. Lareau
    • , Hayley J. Zullow
    • , Nora Fortoul
    • , Nathanael S. Gray
    • , James E. Bradner
    • , Ho Man Chan
    •  & Cigall Kadoch
  • Article |

    Jung et al demonstrate that TMEM9 facilitates vacuolar-ATPase assembly to enhance vesicular acidification, thereby promoting activation of Wnt signalling and development of colorectal cancer.

    • Youn-Sang Jung
    • , Sohee Jun
    • , Moon Jong Kim
    • , Sung Ho Lee
    • , Han Na Suh
    • , Esther M. Lien
    • , Hae-Yun Jung
    • , Sunhye Lee
    • , Jie Zhang
    • , Jung-In Yang
    • , Hong Ji
    • , Ji Yuan Wu
    • , Wenqi Wang
    • , Rachel K. Miller
    • , Junjie Chen
    • , Pierre D. McCrea
    • , Scott Kopetz
    •  & Jae-Il Park

News & Comment

  • News & Views |

    During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

    • Yang Yang
    •  & Hongtao Yu
  • News & Views |

    Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

    • J. Paul Luzio
  • News & Views |

    The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

    • Paola Kuri
    •  & Panteleimon Rompolas
  • News & Views |

    Classical actin-dependent, integrin-mediated cell–matrix adhesions disassemble before mitotic rounding. Yet, to transmit positional information and facilitate daughter-cell separation, dividing cells maintain connections to the matrix. A previously unidentified class of actin-independent integrin adhesions may fulfil this task.

    • Ronen Zaidel-Bar
  • News & Views |

    β-catenin regulates cell–cell adhesion and maintains stemness through Wnt signalling, but how these functions are mechanistically related is not fully understood. A study now identifies CRAD as the mechanistic link, providing insight into how dysregulation of epithelial adhesion contributes to Wnt-driven tumorigenesis.

    • George Eng
    • , Jonathan Braverman
    •  & Ömer H. Yilmaz

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