Nature Cell Biology - ncb Current issue : July 2009 - Vol 11 No 7
- Protein translation
eIF4GI triggers metastasis - Transmitting tauopathy
- Light limits plant cell division
Latest content
Advance online publication
TIP5 acetylation alters heterochromatin formation
Letter by Zhou et al.The chromatin remodeller NoRC silences rDNA by establishing heterochromatin. Grummt and colleagues show that TIP5, a subunit of NoRC, is acetylated by MOF and deacetylated by SIRT1 at Lys 633. Acetylation decreases TIP5 binding to rDNA promoter-associated RNA, leading to altered heterochromatin formation. TIP5 acetylation can be modified by changes in metabolism.
Advance online publication
Lack of mitochondrial fission impairs neuronal function
Letter by Ishihara et al.Mihara and colleagues show that mice that lack the fission mitochondrial GTPase Drp1 die during embryonic development. Although Drp1 is not required for apoptosis, the absence of Drp1 leads to neuronal and synaptic defects due to a failure of elongated mitochondria to reach distal parts of axons.
Nature Milestones in
Cytoskeleton
Nature Milestones in Cytoskeleton focuses on the pivotal breakthroughs in cytoskeleton research over the past 60 years — from the discovery of actomyosin to the identification of molecular motors, and from fluorescence analogue cytochemistry and differential interference contrast microscopy to single-molecule in vitro assays.
Microbial host cell subversion
To highlight advances in our understanding of the mechanisms by which microorganisms tailor cellular pathways to their own needs, Nature Reviews Microbiology and Nature Cell Biology present a set of specially commissioned articles that focus on some of the key pathways in host cells that are subverted by microorganisms during infection or colonization. These articles are freely available to registered users for 2 months after publication.
The Signaling Gateway
The one-stop free resource for cell signaling researchers.
The UCSD-Nature Molecule Pages has just published its 500th expert-authored, peer-reviewed Molecule Page. Each month, Nature Publishing Group publishes five to ten of these comprehensive, freely available review articles on a diverse set of signaling molecules ranging from transcription factors to membrane receptors. Our new user guide provides a quick overview of the anatomy of a published Molecule Page.
Structural Genomics Knowledgebase
A window onto the world of protein structure has opened with the new, free PSI-Nature Structural Genomics Knowledgebase (PSI SGKB). The site is designed to turn the products of the Protein Structure Initiative into knowledge that is important for understanding living systems and disease, complemented with structural biology updates from Nature Publishing Group.
