February 1998

February 1998 volume 16 number 2     OPINION Editorial   No payoff without delivery  p 115   Biodiversity: Knowledge is power  p 115   Commentary   Agricultural genomics comes of age  p 116 William E. Timberlake   DNAP is caught in the tobacco firestorm  p 118 Russ Hoyle   Correspondence   Single nucleotide polymorphism wars?  p 120 Jean-Marie Chauvet   Xenotransplantation moratorium  p 120 Ian Kennedy and Herb Sewell1   ANALYSIS Business & Regulatory News   New European clinical trial regulations are "unacceptable" to industry  p 124 Sylvia Davidson   USDA asks "Can organic foods be recombinant?"  p 127 Jeffrey Fox   HGS launches "first" genomics product in clinic  p 129 Andrew Marshall   Thrombolytics still ahead, despite study that favors angioplasty  p 130 Vicki Brower   German Greens attenuate their genetic resistance  p 130 Ellen Perrenboom   EPA ban on bromoxynil undercuts Calgene's transgenic cotton  p 132 Jeffrey Fox   US courts disagree on generic drug exclusivity  p 132 Ken Chahine   Regional stock exchanges trade biotechnology stock options  p 133 Michael Francisco   Research News   Getting to the heart of growth factor delivery  p 134 Tom Tice and Jay Staas   Opening doors for exogenous agents  p 135 Russell O. Potts and Yuri A. Chizmadzhev   Drug delivery models transported to a new level  p 136 Elazer R. Edelman and Mark Lovich   Aneuploidy and cancer: Vintage wine in a new bottle?  p 137 Harvey Bialy   Bacterial delivery of DNA evolves  p 138 Darren E. Higgins and Daniel A. Portnoy   An intoxicating switch for plant transgene expression  p 140 Christiane Gatz   FEATURES   Breathing life into protein drugs  p 141 John Patton   Bt resistance management  p 144 William H. McGaughey, Fred Gould, and Wendy Gelernter   Regional Development   Making magnets to global biotechnology people  p 147 John Hodgson   Investment indicators show US is still ahead  p 149 Riku Lähteenmäki and John Hodgson   Biotechnology unscathed in Korean finance crisis?  p 151 Asako Saegusa   RESEARCH REVIEW   Improving protein therapeutics with sustained-release formulations  p 153 Scott D. Putney* and Paul A. Burke   RESEARCH ARTICLES   The delivery of angiogenic factors to the heart by microsphere therapy   p 159 Margarete Arras, Hanke Mollnau, Rudolf Strasser, Robert Wenz1, Wulf D. Ito*, Jutta Schaper, and Wolfgang Schaper   Topical antibody delivery systems produce sustained levels in mucosal tissue and blood  p 163 Patricia Y. Kuo, Jill K. Sherwood1Ý, and W. Mark Saltzman*   In vivo electrically mediated protein and gene transfer in murine melanoma  p 168 Marie-Pierre Rols, Christine Delteil, Muriel Golzio, Patrick Dumond, Suzie Cros, and Justin Teissie*   Sustained local drug delivery from a radiopaque implanted reservoir  p 172 Leo H. Koole1*, Marc-Anton B. Kruft1, Yvette B.J. Aldenhoff1,2, Nicolette E. van 't Oost1, Marinus J.P.G. van Kroonenburgh2, and Frederik H. van der Veen3   An ethanol inducible gene switch for plants used to manipulate carbon metabolism  p 177 Mark X. Caddick, Andrew J. Greenland1, Ian Jepson1, Klaus-Peter Krause2, Nan Qu2, Kay V. Riddell, Michael G. Salter, Wolfgang Schuch1, Uwe Sonnewald2, and A. Brian Tomsett*Ý   Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes  p 181 Guido Dietrich1,6, Andreas Bubert1,6, Ivaylo Gentschev1, Zeljka Sokolovic1, Andreas Simm2, Andre Catic3, Stefan H.E. Kaufmann3,4, Jürgen Hess3,4, Aladar A. Szalay1,5, and Werner Goebel1,*   Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast  p 186 Catherine Duport, Roberto Spagnoli1, Eric Degryse2, and Denis Pompon*   Design, synthesis, and application of a Protein A mimetic  p 190 Rongxiu LiÝ, Victor Dowd1, David J. Stewart+, Stephen J. Burton1, and Christopher R. Lowe*   Isolation of neuronal precursors by sorting embryonic forebrain transfected with GFP regulated by the T(alpha)1 tubulin promoter  p 196 Su Wang, Hong Wu, Jinwen Jiang, Thomas M. Delohery1, Frank Isdell2, and Steven A. Goldman*   RESOURCES Patents   Managing genomics-based intellectual property  p 203 David Abraham   WWW Guide   Proteomics: One small step for a digital computer, one giant leap for humankind  p 206 Michael J. Geisow   Industry Trends   The business of pharmacogenomics  p 209 Aris Persidis