Research

This list contains the 50 most recently published research articles, including advance online publication articles that have not yet been published in a journal issue.

Showing: 1–25 of 50

AOP
  1. Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer AOP

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    Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.

  2. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis AOP

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    Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

  3. Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

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    In vivo reprogramming of astrocytes to dopamine neurons improves motor behavior in a mouse model of Parkinson's disease.

    See also: News and Views by Stephen B Dunnett et al.

  4. Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

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    Targeted editing of single base pairs is achieved in monocot rice and dicot tomato using Target-AID (Cas9 activation-induced cytidine deaminase fusion).

    See also: News and Views by Andrew May

  5. The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit

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    Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies.

    See also: News and Views by Joseph C Kvedar et al.

  6. Prediction of potent shRNAs with a sequential classification algorithm

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    The most effective shRNAs to silence a gene are calculated by a machine learning algorithm.