Volume 36 Issue 2, February 2018

Electron microscopy of T cells on a fluid lipid bilayer, supported by mesoporous silica micro-rods (pseudocolored). Cheung et al. show that this scaffold can be used to mimic antigen presentation to T cells, improving the outcome of T-cell expansion for adoptive cellular therapies (p 160). Image credit: Alexander Cheung, Sandeep Koshy and David Zhang.

Editorial

A less than ideal Deal

The UK government's strategic plan for the life sciences is short on ambition and capital.

Editorial 06 Feb 2018

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No research in Correspondence

Nature Biotechnology will no longer publish research in its Correspondence section.

Editorial 06 Feb 2018

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News

FDA warns public of dangers of DIY gene therapy

Eric Smalley
News 06 Feb 2018
Gut bacteria link to immunotherapy sparks interest

Brian Owens
News 06 Feb 2018
Spark's gene therapy price tag: $850,000

News 06 Feb 2018
Roche pays $1.7 billion to target tumors' genetic signatures

News 06 Feb 2018
Approval of first tumor gene panel sends shockwaves through labs

Mark Ratner
News 06 Feb 2018
California voters and CIRM—will lightning strike twice?

Laura DeFrancesco
News 06 Feb 2018
Around the world in a month

News 06 Feb 2018
US tax reform may jeopardize orphans

Chris Morrison
News 06 Feb 2018

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Data Page

2017—venture funding goes into overdrive

Laura DeFrancesco
Data Page 06 Feb 2018
Drug pipeline: 4Q17

Laura DeFrancesco
Data Page 06 Feb 2018

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News Feature

Fresh from the biotech pipeline—2017

A positive regulatory environment, combined with a raft of drug approvals that included the first US gene therapy, buoyed the sector in 2017. The FDA's flexibility and focus on marketplace competition is likely to galvanize innovators in the coming year. Chris Morrison reports.

Chris Morrison
News Feature 22 Jan 2018

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Correspondence

Rationalizing governance of genetically modified products in developing countries

Ademola A Adenle
E Jane Morris
John Komen
Correspondence 06 Feb 2018
An alternative proposal to the destruction of abandoned human embryos

Norbert Gleicher
Arthur L Caplan
Correspondence 06 Feb 2018

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Patents

Tertiary patenting on drug–device combination products in the United States

Drug–device combination products are becoming increasingly prevalent, with many lasting years beyond the expiration date of primary and secondary patents on the drug itself.

Reed F Beall
Aaron S Kesselheim
Patents 06 Feb 2018
Recent patents in neoantigens and neoepitopes

Patents 06 Feb 2018

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News & Views

PrePAIRing Cas9s for screening success

Orthogonal CRISPR–Cas9 nucleases enable more efficient high-throughput screens for deciphering genetic interactions.

Zhuo Zhou
Wensheng Wei
News & Views 06 Feb 2018
Making brain proteomics true to type

Two independent but related strategies use unnatural amino acid incorporation to enable in vivo cell-type-specific proteomics in the mouse brain.

Rashaun S Wilson
Angus C Nairn
News & Views 06 Feb 2018
Research Highlights

News & Views 06 Feb 2018
Putting a number on neoepitope quality

Irene Jarchum
News & Views 06 Feb 2018

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Brief Communication

Functional interrogation and mining of natively paired human V_H:V_L antibody repertoires

Libraries of natively paired human VH:VL chains enable screening of the human B-cell repertoire in yeast.

Bo Wang
Brandon J DeKosky
George Georgiou
Brief Communication 08 Jan 2018
Labeling and identifying cell-specific proteomes in the mouse brain

Labeling of cell-type-specific proteomes in the brains of live mice is enabled by an orthogonal-amino-acid approach.

Toke P Krogager
Russell J Ernst
Jason W Chin
Brief Communication 18 Dec 2017

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Article

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

T cells are readily expanded in culture using a system that presents membrane-bound and soluble cues in a natural context.

Alexander S Cheung
David K Y Zhang
David J Mooney
Article 15 Jan 2018
Dual gene activation and knockout screen reveals directional dependencies in genetic networks

Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional dependency.

Michael Boettcher
Ruilin Tian
Michael T McManus
Article 15 Jan 2018
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens

Combinatorial CRISPR screens are improved by using Cas9 enzymes from two different organisms.

Fadi J Najm
Christine Strand
John G Doench
Article 18 Dec 2017

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Letter

Retrieval of a million high-quality, full-length microbial 16S and 18S rRNA gene sequences without primer bias

More of the diversity present in any microbiome is revealed by a method to sequence 16S rRNA that avoids primer bias.

Søren M Karst
Morten S Dueholm
Mads Albertsen
Letter 01 Jan 2018

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Corrigendum

Correction: Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

Robert M Bowers
Nikos C Kyrpides
Tanja Woyke
Corrigendum 06 Feb 2018
Correction: Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission

Andy Greenfield
Peter Braude
Anthony C F Perry
Corrigendum 06 Feb 2018
Correction: Corrigendum: Reproducing with DNA

Malorye Allison Branca
Corrigendum 06 Feb 2018

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Erratum

Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Trung Van Chu
Timm Weber
Ralf Kühn
Erratum 06 Feb 2018

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Careers and Recruitment

Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy

A standard taxonomy and visualization methods can provide postdoctoral scholars with tools to critically evaluate their career prospects.

Hong Xu
Richard S T Gilliam
Tammy R L Collins
Careers and Recruitment Open Access 15 Jan 2018
People

Careers and Recruitment 06 Feb 2018

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Volume 36 Issue 2, February 2018

Editorial

News

Data Page

News Feature

Correspondence

Patents

News & Views

Brief Communication

Article

Letter

Corrigendum

Erratum

Careers and Recruitment

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