Volume 35 Issue 9, September 2017
Antisense oligonucleotides are commonly generated as mixtures of a vast number of stereoisomers. A scalable chemical method (p 845) now provides control over phosphorothioate stereochemistry, enabling production of antisense oligonucleotides with high stereopurity. Iwamoto et al. show that the properties of stereoisomers vary substantially depending on their stereochemistry, with some mediating better target RNA cleavage than a mixture of stereorandom isomers. Image credit: Eric D. Smith
Editorial
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