Volume 35 Issue 6, June 2017

A cross-section of a cell aggregate with several human inner ear organoids, highlighting sensory hair cells (red and yellow), supporting cells (green), the actin-rich luminal surface (purple), and nuclei of all cells (cyan). Koehler et al. (p 583) describe the generation of human inner ear organoids from pluripotent stem cells. Image credit: Emma Longworth-Mills and Karl R. Koehler

Editorial

Patient-centered drug manufacture

Bedside production of protein drugs could help payers by lowering drug prices. It may ultimately lead to individualized treatments.

Editorial 07 Jun 2017

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News

Industry 'road tests' new wave of immune checkpoints

Ken Garber
News 07 Jun 2017
Interest rekindles in drug cocktails that reprogram cells

Cormac Sheridan
News 07 Jun 2017
Verily chases a perfectly healthy human

News 07 Jun 2017
After Glybera's withdrawal, what's next for gene therapy?

Melanie Senior
News 07 Jun 2017
CAR-T death strikes Kite

News 07 Jun 2017
First deuterated drug approved

Charles Schmidt
News 07 Jun 2017
Eat a water bottle or two

News 07 Jun 2017
Around the world in a month

News 07 Jun 2017

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News Feature

Hanging on a thread

Several companies are now banking on bioengineered silk to create a new generation of textiles and materials...and a necktie. Laura DeFrancesco investigates.

Laura DeFrancesco
News Feature 07 Jun 2017

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Correspondence

Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics

Marc Hafner
Mario Niepel
Peter K Sorger
Correspondence 07 Jun 2017
The illusion of control in germline-engineering policy

Harald König
Correspondence Open Access 07 Jun 2017

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Commentary

Making individualized drugs a reality

Magistral drug preparation offers a model to circumvent many of the technological, regulatory and financial challenges that prevent provision of the right drug at the right time to the right patient.

Huub Schellekens
Mohammed Aldosari
Enrico Mastrobattista

Nature Outlook:

The future of medicine
Commentary 05 Jun 2017

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Patents

Patents as collateral for securitization

Patents are important assets for biotech organizations, not only for protecting inventions but also as assets to raise monies.

Nishad Deshpande
Asha Nagendra
Patents 07 Jun 2017
Recent patents in microbiomes and microbial genomics

Patents 07 Jun 2017

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News & Views

Building the human inner ear in an organoid

Inner ear organoids will facilitate disease studies and drug screening.

Vidhya Munnamalai
Donna M Fekete

Collection:

Organoid research
News & Views 07 Jun 2017
Manufacture of CAR-T cells in the body

Engineered T cells for cancer therapy are produced in the mouse bloodstream, avoiding the need to harvest T cells and manipulate them ex vivo.

Johanna Olweus
News & Views 07 Jun 2017
Research Highlights

News & Views 07 Jun 2017
A spring collection of designer yeast chromosomes

Katarzyna Marcinkiewicz
News & Views 07 Jun 2017

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Perspective

Open-source, community-driven microfluidics with Metafluidics

A community-led initiative will enable users to design, share, refine and innovate fluidic devices.

David S Kong
Todd A Thorsen
Peter A Carr
Perspective Open Access 07 Jun 2017
The promise of organ and tissue preservation to transform medicine

Sebastian Giwa
Jedediah K Lewis
Mehmet Toner
Perspective 07 Jun 2017

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Article

Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene

Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression of mouse xenograft tumors.

Zhang-Hui Chen
Yan P Yu
Jian-Hua Luo
Article 01 May 2017
Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

Analysis of RNA-seq data from individual developing mouse motor neuron cells with topological data analysis sheds light on crucial cell-fate decisions during neurogenesis.

Abbas H Rizvi
Pablo G Camara
Raul Rabadan
Article 01 May 2017
CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Regulatory elements for specific human genes are rapidly identified with CRISPR epigenome editing.

Tyler S Klann
Joshua B Black
Charles A Gersbach

Collections:

Department of Biomedical Engineering at Duke University

The 3D genome
Article 03 Apr 2017

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Letter

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

Jatin Roper
Tuomas Tammela
Ömer H Yilmaz

Collection:

Organoid research
Letter 01 May 2017
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.

Kevin P O'Rourke
Evangelia Loizou
Scott W Lowe

Collection:

Organoid research
Letter 01 May 2017
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

Human pluripotent stem cells are differentiated into inner ear organoids containing cells similar to hair cells and sensory neurons.

Karl R Koehler
Jing Nie
Eri Hashino

Collections:

Stem cells from development to the clinic

Organoid research
Letter 01 May 2017

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Careers and Recruitment

A synthetic biology approach to integrative high school STEM training

Synthetic biology–based group activities provide opportunities for integrative STEM training and literacy, while lowering barriers for high school students to become interested in science careers.

Sutherland Dubé
Doug Orr
Hans-Joachim Wieden
Careers and Recruitment 07 Jun 2017
People

Careers and Recruitment 07 Jun 2017

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Volume 35 Issue 6, June 2017

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