Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

A DNA-based T cell receptor reveals a role for receptor clustering in ligand discrimination

Taylor, M.J., Husain, K., Gartner, Z.J., Mayor, S. & Vale, R.D. Cell 169, 108–119.e20 (2017)

Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain

Lee, D. et al. Nat. Methods 10.1038/nmeth.4234 (2017)

Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes.

Praetorius, F. & Dietz, H. Science 355, eaam5488 (2017)

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

Scoles, D.R. et al. Nature 544, 362–366 (2017)

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Becker, L.A. et al. Nature 544, 361–371 (2017)